A complex subject
House systems, as a topic, can involve many issues to consider depending upon how deep your understanding of astrology is, the type of chart you are working with, and the task that you are addressing with your interpretation of the chart.
A few brief comments can be made. I have made longer comments concerning the nature of the house systems --- I won't replicate those lengthy explanations here, although you might wish to search for them.
The quadrant house systems, such as the Placidus, utilize a time/place determination for the MC great circle and it's 90 degree offset circle's intersection with the ecliptic plane (Earth-Sun orbital plane) as the basis for its structure. Due to the Earth's tilt as well as latitude distortion affecting the intersecting points, the quadrants are seldom 90 degrees apart as measured on the ecliptic plane. The various house systems divide those quadrature sections either by time-of-rising or by distance or some combination of the two. There are also other approaches to defining houses, not all of which have 12 houses. There are also equal house systems tarting with the MC or the Asc. points.
In a theoretical sense, each house system (or group of similar-based systems) has a distinct character and influence upon how a chart is read. I doubt that even one percent of today's astrologers recognize, care and use more than a single system, and few know why they prefer one system over another.
I don't wish to give you the wrong impression about answering this question. It is a good question, but the answers are lengthy and may not mean much to you at this point in your studies. I would suggest that you explore only a limited set of house systems, perhaps the Placidus, Equal House (from the Asc.) and either the Campanus or the Regiomontanus --- these latter two will provide a different distortion presentation from each other and from the Placidus. In this way you will see differences that may fit with your early expectations.
Dave