Umbrae has linked you to the Tirage en Croix, which is where the idea of quintessence in a tarot reading comes from.
The word "quintessence", and its concept in tarot, is derived from alchemy. In Western alchemy, there are 5 elements: Air, Fire, Water and Earth, and a fifth - Quintessence (meaning "fifth essence") - which is a mysterious element that contains the essence of all the others but also contains the Spirit. And so in a reading, the quintessence card - derived numerically from the other cards - is the sum of the essence of the other cards, which also brings an overarching spiritual direction to the reading. Given its nature, it can't be read in isolation from the other cards, but neither is it a card like any other. In practice I often find that it is the same card (always a Major of course) as one of the other cards, so that you can easily see where the throw is weighted.
I have to add that in the Tirage en Croix, at least, the quintessence card is not simply a complement, but is a vital part of the spread. I use the quintessence card with other spreads, but only where it makes sense to make it as an important part of the reading, otherwise not.
The Base or Shadow card is the card at the bottom of the deck, which can give you some information about things that are withheld, or shadowed, in the reading.