I'd say that you being out-of-sorts/feeling vulnerable affects how you receive that deck.
Imagery that is usually engaging, somehow - you see in a different light.
And it's a subconscious reaction.
When I'm ill - be it with an ailment, or that I didn't sleep enough - I just become more sensitive to everything (of which I'm already highly sensitive. Lol). I can cope with far less information and interactions with people - somebody talking to me may just grate on my nerves, and things I usually take in my stride daily - may seem like a huge mountain all-of-a-sudden. The daily ride on the bus may seems like a huge invasion of my personal space. Daily traffic noise walking up my road might make me want to scream - when I usually hardly notice it (I automatically filter it out - so my filters have stopped working because I'm unwell).
I've not had a deck actually make me feel more ill, when already ill - but then I usually instinctively choose to work only with decks that I know will have a calming or cheering effect on me. Next time - I'll deliberately try it to find out.
Recently I've been fascinated to discover that the colour scheme of Dame Fortune's Wheel Tarot (Paul Huson) - actually switches me into parasympathetic mode, i.e. I can feel my nervous system slow down and get quieter - just as if I've been doing a relaxation meditation.