I can't say I regret ignoring because I don't think I ever receive a great advice. I used a spread one of these days about my career and both paths are good (one was great, though). I ended up following the "greater path" and it didn't lead me anywhere, so... I've lost nothing xD
I do have "what if's". I did a spread about my relationship with my dad and it was telling me to talk with him calmly (as it seems, we have karma from our past life and I had to let go) because I could have gotten into trouble in the future. I would say everything I wanted to say all these years, but not in the best place or best timing. One of those explosive moments, I guess. So I did. I talked with him and let go of whatever feelings I had in a way to not regret it (and kinda hoping it would change our relationship). It didn't change a thing... At least, apparently. So I'm in those "what if" situations. I swallowed my pride, I did what I needed to do (yes, if we had karma... I had to do something) and it didn't go the way I expected, I guess.