You asked me for a “general” and so I really hope this reading has some relevance to some area of your life!
1. This is what I should take more seriously (embrace) – Fehu
The literal meaning of this is “cattle” which can be interpreted to mean wealth – your personal wealth measured in terms of finances, social standing (the two are so very tied together in our society) and personal power.
In this reading the understanding I have of this rune is that you have to give a little to gain a little. And if you want to gain a lot then you have to really put the effort in; this will of necessity involve time, attention and care. If what you seek is a flourishing anything – business, relationship, family life – – then you have to invest yourself in it. Take it seriously, spend time and attention on it. If you don’t, whilst these things probably won’t disappear neither will they prosper and develop as they could. We have all met the people who don’t get the promotions, whose romantic interests don’t get anywhere, and whose friendships gradually fade away.
Fehu says that if you want the wealth (in any sphere of life, and measured emotionally, financially or in any other way) then you have to do the work.
2. This is what I should take less seriously (let go of) – Isa
In connection with this rune I see the reading as being an attitude to let go of, and it comes over as over-thinking situations. Overmuch thought about things can lead you to not actually getting anything done. You cannot keep waiting for the right time – sometimes you just have to get stuck in and hope for the best.
Isa discusses self-control which is in general a good quality that restrains us from ill-thought out action, but for its slightly more negative aspect I think about the nature of an icicle; it is static and whilst it does grow it does this very, very slowly. So although in certain situations a rune telling you to stop and exercise more self control, as being "something to let go" can be a very good thing, I feel that here you are being told that the time for hanging around waiting for something to happen is over. You are not making any perceptible progress and instead you need to take action in line with Fehu’s advice.
I hope this reading gels!