DE,
To answer your (and others) questions about significators:
A horary chart is cast for the moment that the Astrologer understands the question. It is, or should be, the culmination of a series of events, whereby the person asking the question (the 'querent') thinks carefully about what it is they want to know and phrases the question as best they can.
They then negotiate the question with the Astrologer who will answer their question. This negotiation is to ensure that the Astrologer knows and understands the question and the question is one that can be answered by the horary process (there are very few that can't but one that would fall into that category would be 'Does God exist?'
Once the Astrologer knows and understands, the moment is right for the question to be asked and a chart is cast. The chart is a chart for the question and is in no way derived from birth charts or any other charts.
In both the charts I cast, one in the morning and one in the mid afternoon and on different days, I ended up with a Mercury ruled sign on the Ascendant and a Jupiter ruled sign on the descendent. For the 'universe' at least the two questions are intimately related (and of course you know that they are).
Unless there are very good reasons not to, the planet ruling the Ascendant is the significator asking the question, in this case Mercury signifies you in both charts. In questions about relationships, as these were, the other person is signified by the planet ruling the Descendent. In both cases this was Jupiter, so Jupiter signifies him. In the second horary, Jupiter is in the Seventh House - the House it rules, and also in Pisces, one of the signs it rules. This signifies that in the situation he is in his own home and as the question relates to him leaving his wife or getting her to leave him, that is actually quite important. If his wife were signified by the Moon, she too would be at home with him (the Moon being in the seventh and in Pisces) In that sense she, the wife, is in Pisces, that is nothing to do with her Sun sign at all.
Now do signifcators change regularly. Horary practitioners take the view that if you keep asking the same, or very closely related questions with short intervals in between that you will end up with charts that don't make sense. This is thought to be because the scenario in which this would happen is that the querent will not take 'No' for an answer (obviously if the first answer is what they want to hear they don't ask again). If the querent will not listen to the answer then the 'universe' will not bother repeating the answer.
Now it's a different matter if the querent, goes away, thinks about the answer waits for the circumstances to change and then comes back and asks again. Thus if DE were to wait till he actually does leave his wife, or throws her out, then the circumstances have changed and further questions could be asked - though I think she would be on the first flight there, instead!!
Modern Astrologers tend to regard horary with suspicion because it doesn't fit in with a modern view of the universe. It is base much more on the idea that the universe is not disinterested matter but is part of an organised living Cosmos that binds us all together. 'As above, so below....' For the Tarot Reader the ideas behind horary will be very familiar, even if the methods are not.
Going back to the main theme, I think Astraea's advice seems very sensible. Conditions may change and clearly you have plans to get there quickly if necessary. Astraea also thought that the coming opposition of Mercury and Saturn might well mark a change in circumstances. As I think from memory that is next week, that's not a long delay and you could well stll go ahead with your plans if his circumstances change in the desired manner.